Thread:SparkyChidori27/@comment-30554397-20161120173519/@comment-30554397-20161222200210

Read it again, "Through experimentation, Saemon was able to recreate that process in a non-Uchiha's brain by causing those exact same enzymes to fuse together allowing the activation for the sharingan. The sharingan that activates is the recipient's own personal sharingan and works and functions like a regular sharingan going through the same process as the Uchiha Clan's sharingan, and possibly becoming a MS. Saemon also massed produced a large quantity of spare sharingan by using Hashirama Senju's cells as a base which he gave to Danzō Shimura. However, do to the little amount of Hashirama's cells needed to produce the spares the recipient will not activate the Rinnegan, unless further modified. Danzō Shimura only activated one Rinnegan in his right eye because of the large amount of Senju and Uchiha cells embedded in his body.".

The serum itself is not made up of senju cells its a culmination of activated enzymes that come together in the recipient's brain that force the activation of a sharingan due to the components of the serum and enzymes that already exist in the recipient. Nor does anything in the naruto universe ever say that Senju or Uzumaki dna prevent or negate a MS blindness because had that been true danzo's would have been immune to the adverse effects of Izanagi. When one possesses Senju and Uchiha dna its possible but no guarantee that the recipient will awaken the Rinnegan, by activating the Rinnegan it restores the sight of someone who has used izanagi or izanami, also possessing and EMS prevents the wielder from going blind. And yes six paths chakra could technically be used to modify the serum leading the recipient to activate a rinnegan but not a rinne sharingan.